Titin isoform expression in aortic stenosis
نویسندگان
چکیده
منابع مشابه
Titin isoform expression in aortic stenosis.
Titin is a giant sarcomeric protein that plays a major role in determining passive myocardial stiffness. The shorter N2B isoform results in a higher passive myocardial stiffness than the longer N2BA isoform. We hypothesised that the expression of the short N2B isoform would be increased in patients with aortic stenosis compared with healthy controls in response to pressure overload, in order to...
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OBJECTIVE Titin isoform expression patterns were examined to explain previously observed genetic differences in rat cardiac passive tension. METHODS Rat ventricles from male spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats (normotensive) were used to analyze the titin isoform patterns. The hypertensive status was verified by blood pressure measurements and heart weight to body wei...
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ژورنال
عنوان ژورنال: Clinical Science
سال: 2009
ISSN: 0143-5221,1470-8736
DOI: 10.1042/cs20080248